Open Positions

We are looking for two highly motivated PhD candidates (one in bioinformatics and one in experimental biology) interested in investigating how cancer cells change the 3D genome to hijack gene regulation for aberrant expression of oncogenes from high-level genomic amplifications. The bioinformatics part of the project will involve whole genome sequencing and epigenetic analysis of several hundred tumor samples from breast and lung cancer patients to identify significantly recurrent changes to their 3D genome. In the experimental biology part, we will model recurrent oncogenic changes to the 3D genome observed in these cancers using CRISPR-based approaches to understand the mechanism of oncogenic transcription and resulting novel cancer vulnerabilities..